News: Public Science Insights: Where did we come from? Tracing the migrations...
In 1831 naturist Charles Darwin embarked on his famous and memorable voyage in the Beagle, an expedition that lasted almost 5 years. Equipped with hardly more than a telescope and insatiable curiosity...
View ArticleNews: Public Science Insights: Did ancient bacterial mRNA genes have introns?
Ancient bacterial mRNA genes quite possibly had introns, according to recent findings by Dr. Wang and colleagues.All current bacterial mRNA genes have no intron (nucleotide base sequence interrupting...
View ArticleNew Article: Insights Into Signaling in Cell-Based Therapy for Heart Disease
Over the past several decades, stem cell therapy for heart disease has been translated from the bench to the bedside and in clinical trials improves cardiac structure and function in both ischemic and...
View ArticleNew Article: Identification of very small open reading frames in the genomes...
Viruses of the family Rhabdoviridae infect a broad range of hosts from a variety of ecological and geographical niches, including vertebrates, arthropods, and plants. The arthropod-transmitted members...
View ArticleNew Article: Prediction With Dimension Reduction of Multiple Molecular Data...
Predictive modeling from high-dimensional genomic data is often preceded by a dimension reduction step, such as principal component analysis (PCA). However, the application of PCA is not...
View ArticleNew Article: Reverse Nearest Neighbor Search on a Protein-Protein Interaction...
The associations between proteins and diseases are crucial information for investigating pathological mechanisms. However, the number of known and reliable protein-disease associations is quite small....
View ArticleNews: Biomedical Engineering and Computational Biology: Special Collection on...
Biomedical Engineering and Computational Biology is now accepting papers for a Special Collection on Machine Learning for Biomedical Informatics.Please submit by December 31, 2017 to be...
View ArticleNews: Biomedical Informatics Insights: Special Collection on Precision and...
Please note that this Special Collection title has changed from "Approaches to Measuring the Interaction of Trait (Genetic) and State (Clinical) Data" to "Precision and Individualized Medicine"
View ArticleNews: Cancer Informatics: Special Collection on Human Protein Coding Genes...
Cancer Informatics is now accepting papers for a Special Collection on Human Protein Coding Genes for Cancer.Please submit by December 31, 2017 to be conside...
View ArticleNews: Cancer Informatics: Special Collection on Signal Processing...
Cancer Informatics is now accepting papers for a Special Collection on Cancer Biomarkers, Genomics, Proteomics, and Metabolomics AnalysisPlease submit by October 1, 2017 to ...
View ArticleNew Article: Linear-In-Flux-Expressions Methodology: Toward a Robust...
Quantitative Systems Pharmacology (QSP) modeling is increasingly used as a quantitative tool for advancing mechanistic hypotheses on the mechanism of action of a drug, and its pharmacological effect in...
View ArticleNew Article: Immuno-Oncology Integrative Networks: Elucidating the Influences...
In vivo and in vitro functional phenotyping characterization was recently obtained with reference to an experimental pan-cancer study of 22 osteosarcoma (OS) cell lines. Here, differentially expressed...
View ArticleNew Article: Consistency and Variability of DNA Methylation in Women During...
Prior DNA methylation (DNA-m) analyses have identified cytosine-phosphate-guanine (CpG) sites, which show either a significant change or consistency during lifetime. However, the proportion of CpGs...
View ArticleNew Article: Multiple Testing in the Context of Gene Discovery in Sickle Cell...
The issue of multiple testing, also termed multiplicity, is ubiquitous in studies where multiple hypotheses are tested simultaneously. Genome-wide association study (GWAS), a type of genetic...
View ArticleNew Article: Embedded-Based Graphics Processing Unit Cluster Platform for...
High-end graphics processing units (GPUs), such as NVIDIA Tesla/Fermi/Kepler series cards with thousands of cores per chip, are widely applied to high-performance computing fields in a decade. These...
View ArticleNews: Evolutionary Bioinformatics: Special Collection on Algorithm...
Evolutionary Bioinformatics is now accepting papers for a Special Collection on Algorithm development for evolutionary biological computation. Enter promo code EBO-18 on Step 2 of the submission...
View ArticleNew Article: Popmarker: Identifying Phylogenetic Markers at the Population Level
As phylogenomic approach becomes a common practice for constructing true bacterial phylogenies, it has become apparent that single molecular markers such as 16S ribosomal DNA often lead to...
View ArticleNew Article: Adaptive Multiview Nonnegative Matrix Factorization Algorithm...
The amounts and types of available multimodal tumor data are rapidly increasing, and their integration is critical for fully understanding the underlying cancer biology and personalizing treatment....
View ArticleNew Article: Optimized Next-Generation Sequencing Genotype-Haplotype Calling...
The accurate estimation of nucleotide variability using next-generation sequencing data is challenged by the high number of sequencing errors produced by new sequencing technologies, especially for...
View ArticleNew Article: Complete Mitochondrial Genomes of the Cherskii’s Sculpin and...
The complete mitochondrial (mt) genome is sequenced in 2 individuals of the Cherskii’s sculpin Cottus czerskii. A surprisingly high level of sequence divergence (10.3%) has been detected between the 2...
View ArticleNew Article: Chondroitin Sulfate Inhibits Monocyte Chemoattractant Protein-1...
Monocyte chemoattractant protein-1 (MCP-1) overproduction from inflamed adipose tissue is a major contributor to obesity-related metabolic syndromes. 3T3-L1 embryonic fibroblasts were cultured and...
View ArticleNew Article: xSyn: A Software Tool for Identifying Sophisticated 3-Way...
Background: Constructing gene co-expression networks from cancer expression data is important for investigating the genetic mechanisms underlying cancer. However, correlation coefficients or linear...
View ArticleNew Article: Hierarchical Association Coefficient Algorithm: New Method for...
Hierarchical association coefficient algorithm calculates the degree of association between observations and categories into a value named hierarchical association coefficient (HA-coefficient) between...
View ArticleNew Article: Inhaled Steroids and Active Smoking Drive Chronic Obstructive...
Rationale: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease, and development of novel therapeutics requires an understanding of pathophysiologic phenotypes. Objectives: The...
View ArticleNew Article: A Modified Mean Gray Wolf Optimization Approach for Benchmark...
A modified variant of gray wolf optimization algorithm, namely, mean gray wolf optimization algorithm has been developed by modifying the position update (encircling behavior) equations of gray wolf...
View ArticleNew Article: Gene-Set Reduction for Analysis of Major and Minor Gleason...
The Gleason score (GS) plays an important role in prostate cancer detection and treatment. It is calculated based on a sum between its major and minor components, each ranging from 1 to 5, assigned...
View ArticleNew Article: Bioinformatics Study of m.9053G>A Mutation at the Gene in...
The mitochondrial disease often associated with various illnesses in relation to the activity of cells metabolites and the synthesis of adenosine triphosphate (ATP), including alteration in the...
View ArticleNew Article: Changes in Alternative Splicing as Pharmacodynamic Markers for...
Objective: The aim of the study was to define pharmacodynamic markers for sudemycin D6, an experimental cancer drug that changes alternative splicing in human blood. Methods: Blood samples from 12...
View ArticleNews: Cancer Informatics Special Collection: Ensemble Learning and Deep...
Cancer Informatics is now accepting papers for a Special Collection on Ensemble Learning and Deep Learning in Cancer Genomic and Imaging Data.
View ArticleNews: Evolutionary Bioinformatics Special Collection: Evolution of Non-coding...
Evolutionary Bioinformatics is now accepting papers for a Special Collection on Evolution of Non-coding RNA. Please submit by Decemb...
View ArticleNews: Genetics & Epigenetics Special Collection: Synthetic & Nano-Biology:...
Genetics & Epigenetics is now accepting papers for a Special Collection on Synthetic & Nano-Biology: Engineering Life at Nanoscale.
View ArticleNew Article: Epigenetic Regulation of Gene Expression Induced by Butyrate in...
Colorectal cancer (CRC) is the third most common cause of cancer mortality globally. Development of CRC is closely associated with lifestyle, and diet may modulate risk. A Western-style diet is...
View ArticleNews: Biomedical Engineering and Computational Biology Special Collection:...
Biomedical Engineering and Computational Biology is now accepting papers for a Special Collection on Machine Learning for Biomedical Inf...
View ArticleNews: Bioinformatics and Biology Insights Special Collection: Computational...
Bioinformatics and Biology Insights is now accepting papers for a Special Collection on Computational Modeling to Aid in Drug Discovery and Developmen...
View ArticleNews: Bioinformatics and Biology Insights Special Collection: Computational...
Bioinformatics and Biology Insights is now accepting papers for a Special Collection on Computational Modeling Biological Systems (e.g. Cell Biology P...
View ArticleNew Article: A Metagenomic Analysis of Bacterial Microbiota in the Digestive...
The digestive tract of triatomines (DTT) is an ecological niche favored by microbiota whose enzymatic profile is adapted to the specific substrate availability in this medium. This report describes...
View ArticleNew Article: Exon Mapping in Long Noncoding RNAs Using Digital Filters
Long noncoding RNAs (lncRNAs) which were initially dismissed as “transcriptional noise” have become a vital area of study after their roles in biological regulation were discovered. Long noncoding...
View ArticleNew Article: Diffusion in Tube Dialyzer
Nowadays, kidney failure is a problem of many peoples in the world. We know that the main function of kidney is maintaining the chemical quality of blood particularly removing urea through urine. But...
View ArticleNew Article: MGUPGMA: A Fast UPGMA Algorithm With Multiple Graphics...
A phylogenetic tree is a visual diagram of the relationship between a set of biological species. The scientists usually use it to analyze many characteristics of the species. The distance-matrix...
View ArticleNew Article: Finding the Sources of Missing Heritability within Rare Variants...
Thousands of genome-wide association studies (GWAS) have been conducted to identify the genetic variants associated with complex disorders. However, only a small proportion of phenotypic variances can...
View ArticleNew Article: Polymorphism of 11 Y Chromosome Short Tandem Repeat Markers...
The conventional technique such as patrilocality suggests some substantial effects on population diversity. With that, this particular study investigated the paternal line, specifically Scientific...
View ArticleNew Article: Insights Into Upland Cotton ( L.) Genetic Recombination Based on...
High-density linkage maps are vital to supporting the correct placement of scaffolds and gene sequences on chromosomes and fundamental to contemporary organismal research and scientific approaches to...
View ArticleNews: Biomarker Insights Special Collection: Biomarkers in Conformational...
Biomarker Insights is now accepting papers for a Special Collection on Biomarkers in Conformational Diseases. Please submit by Decemb...
View ArticleNews: Evolutionary Bioinformatics Special Collection: Molecular Diversity and...
Evolutionary Bioinformatics is now accepting papers for a Special Collection on Molecular Diversity and Conservation. Pleas...
View ArticleNews: Evolutionary Bioinformatics Special Collection: Evolution of...
Evolutionary Bioinformatics is now accepting papers for a Special Collection on Evolution of Self-Organized Three Dimensional (3D) or 2D Patterns in ...
View ArticleNews: Evolutionary Bioinformatics Special Collection: Adaptive Evolution of...
Evolutionary Bioinformatics is now accepting papers for a Special Collection on Adaptive Evolution of Human Non-Coding Sequences.
View ArticleNew Article: Development and Retrospective Clinical Assessment of a...
A closed-form integro-differential equation (IDE) model of plasma dilution (PD) has been derived which represents both the intravenous (IV) infusion of crystalloid and the postinfusion period....
View ArticleNews: Genetics & Epigenetics Special Collection: Epigenetics of Time Perception
Genetics & Epigenetics is now accepting papers for a Special Collection on Epigenetics of Time Perception. Please submit by ...
View ArticleNews: Cancer Informatics Special Collection: Epigenetic Network Analysis in...
Cancer Informatics is now accepting papers for a Special Collection on Epigenetic Network Analysis in Cancer Bioinformatics.
View ArticleNews: Biomedical Informatics Insights: Special Collection on: Proceedings...
Biomedical Informatics Insights is now accepting papers for a Special Collection on Proceedings from the Digital Mental Health Conference, London, 2017.Please submit your abstract for considerations by...
View Article
